Background:
Cytomegalovirus infection represents the most common congenital and acquired infection. The symptomatology is very broad and usually non-specific, ranging from asymptomatic forms to status with organ damage or even to severe systemic infection. This makes CMV infection mimic other disorders and diseases.

Material and methods:
Here we report two cases of CMV infection diagnosed after the second month of life in children who were referred to the infectious disease ward for extended diagnosis. Despite the late identification of infection, the clinical manifestation (psychomotor retardation, hearing loss, lenticulostriate vasculopathy) suggested a diagnosis of congenital infection was highly probable.

Results:
The further diagnostic process led to the correct diagnoses of congenital heart defect and cystic fibrosis, and administration of adequate specialist treatment.

Conclusions:
CMV infections are common and it is worthy to remember that the diagnosis of CMV infection can be not the only one in multisymptomatic infants so the thorough differential diagnostics is necessary.